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Conflict of interest: The authors declare they have no competing interests related to this article. Attualmente sono Dirigente Medico di I Livello con la qualifica universitaria di Ricercatore Confermato e sono Responsabile di Progetti di Ricerca. For more information view the SAGE Journals Sharing page. Management of HPV-Related Cervical Disease: Role of p16INK4a Immunochemistry. Oggetto. Join Facebook to connect with Maria Grazia Piccioni and others you may know. Dott.ssa Maria Grazia Carrara, Faculty of Statistics Department of Statistical Sciences, Università degli Studi di Milan-Bicocca. For Ki67 protein, immunoreactivity localization in the parabasal layers or in the lower third of the epithelium was considered “low-level”; Ki67 reactivity in the lower two-thirds or in the full-thickness epithelium was considered “high-level”. Address Sisters By MARIA GRAZIA DONDI - Via Jacopo da Porto Sud, 509, 41126 Baggiovara (MO) In the study by Santos et al (11), p16INK4a positivity was established when sheets or large clusters of contiguous positive cells representing more than 25% of epithelium were identifiable; also p53 nuclear immunostaining was considered positive when found in 25% or more of cells. Further, larger and controlled studies are needed to obtain consensus diagnostic results in order to use these markers in everyday clinical practice as a valid, effective and economically convenient instrument. In specimens of warty/basaloid VSCC, HPV positivity ranged from 62.5% to 100%, p16INK4a immunoreactivity from 76.4% to 100%, and p53 immunostaining was positive in 6.2% of cases. Does human papillomavirus infection imply a different prognosis in vulvar squamous cell carcinoma? Additionally, women with uVIN and no SCC areas had a still lower median age at the time of diagnosis: 36 years (SD 10.8 years). Maria Grazia Porpora 1 , Roberto Brunelli, Graziella Costa, Ludovica Imperiale, Ewa K Krasnowska, Thomas Lundeberg, Italo Nofroni, Maria Grazia Piccioni, Eugenia … The email address and/or password entered does not match our records, please check and try again. IARC. The initial findings of the patients and specimens surveyed were also specified. Reuschenbach et al (18) also evaluated VSCC based on HPV DNA, p16INK4a and p53 expression, with tumor location limited to the anterior vulvar fourchette. Buongiorno, sono la dottoressa Maria Grazia Piccioni e vi do il benvenuto sul mio profilo. Search Google Scholar for this author, Pierluigi Benedetti Panici. The sensitivity and specificity of p16INK4a to detect HPV-associated carcinomas were 100% and 98.7%, respectively, which compares favorably to histological criteria (with 93.8% sensitivity and 35.5% specificity) and to p53 negativity (with 62.5% sensitivity and 93.4% specificity). Normal vulvar epithelium, nondysplastic lesions and HPV-related uVIN and basaloid/warty VSCC were negative for p53, while nuclear and diffuse p53 immunostaining was detected in dVIN and keratinizing VSCC. Sono occupata anche in ambito accademico: sono infatti docente presso il Corso di laurea in Medicina e Chirurgia per la materia di Ostetricia e Ginecologia presso l'Università "La Sapienza" di Roma, nella quale io stessa mi sono lauerata. Cucinotta was born in Messina, Province of Messina, Sicily, Italy. Members of _ can log in with their society credentials below. Search Google Scholar for this author, Pierluigi Benedetti Panici. For more information please contact us. Aggiungi una recensione Fai … HPV16 was the predominant genotype, followed by HPV18 and HPV33. Maria Grazia Piccioni. Viviamo nel periodo molto strano, la gente no ha fiducia, non ci sentiamo sicuri. No age differences were found with respect to the other studies evaluated. Maria Di Grazia. Studies whose full manuscript or baseline characteristics were not available were excluded from our analysis. a case-control study: GYNECOLOGICAL ENDOCRINOLOGY: 2020: 5 recensioni, La Professoressa Maria e' meravigliosa. +2 Altro. +39 339 44 44 247 Casa Piccioni Strada Vecchia Passera-Vedasco 6 28838 Stresa Frazione Passera Italia MILANETTI ALESSANDRO . Login failed. Guarda il profilo completo su LinkedIn e scopri i collegamenti di Maria Grazia e le offerte di lavoro presso aziende simili. Cancer incidence in five continents, Probable nonpapillomavirus etiology of squamous cell carcinoma of the vulva in older women: a clinicopathologic study using in situ hybridization and polymerase chain reaction, Recent advances in the pathology of the vulva, Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee, The etiologic role of HPV in vulvar squamous cell carcinoma fine tuned. Il tuo messaggio. Per contattarmi puoi chiamare il numero +39 347 7868495 mandarmi una email. Most of them showed close areas positive for squamous cell carcinoma (SCC). Risulta sempre disponibile e, in caso di necessità, rintracciabile. The baseline characteristics of the studies were extracted from each article: the first author, journal and year of publication, and the number of specimens examined in relation to the number of patients. A systematic literature search was carried out in the online databases PubMed, EMBASE, Cochrane Library, Clincaltrials.gov and Scopus. Official FaceBook Fan Page Review studies indicated that p16INK4a or p16INK4a/p53 immunoreactivity along with histological diagnostics could adequately classify VIN and its connection to HPV infection. Contatti. Maria Grazia Piccioni; Maria Grazia. A risk of bias across the assessed studies was due to the not perfectly homogeneous interpretation of p16INK4a expression and the different kits used for immunostaining; thus, it will be necessary to standardize the nuclear and cytoplasmic scoring system and the immunohistochemistry technique. Facebook gives people the power to share … Maria Grazia Porpora 1 , Roberto Brunelli, Graziella Costa, Ludovica Imperiale, Ewa K Krasnowska, Thomas Lundeberg, Italo Nofroni, Maria Grazia Piccioni, … Join Facebook to connect with Maria Grazia Piccini and others you may know. p16INK4a, HPV DNA, MIB1 and p53 were examined using immunohistochemical staining, which identified nuclear positivity. Maria Grazia Piccioni . Infatti, si è scoperto che molti dei volatili vengono drogati con cocaina o antidolorifici. However, its expression in vulvar carcinomas, which have a diverse pathogenesis, has not been extensively studied and only a few studies were reported in the scientific literature. oppure compilare il modulo qui di seguito. The key search terms were HPV, VIN, p16INK4a immunochemistry and p53. The remaining 8 studies were included in the review. I have read and accept the terms and conditions, View permissions information for this article. Lavasecco Azzurra di Fassari / Maria Grazia - Laundry Services - Via dei Piccioni, 11, Catania, Italy - Phone Number - … Maria Grazia Piccioni is on Facebook. Adnexal masses are not common in pregnancy. Journal of prenatal medicine, 1 (2). Ho sempre ritenuto la ginecologia una materia importante e necessaria per il benessere della donna e per questa ragione, dopo la laurea in Medicina e Chirurgia, mi sono specializzata presso l'Università La Sapienza di Roma in Ginecologia ed Ostetricia. Facebook gives people the power to share … Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Therefore, the clear recognition of HPV-related lesions should lead to an appropriate strategy of treatment and follow-up. For HPV-related basaloid/warty VSCC, p16INK4 immunostaining was able to distinguish transforming HPV infections better than HPV DNA detection and with higher interobserver agreement. We found that nuclear and cytoplasmic immunostaining for p16INK4a was intense and diffuse in HPV-associated lesions and weak and focal in normal vulvar epithelium, nondysplastic lesions, lichen sclerosus and keratinizing vulvar squamous cell carcinoma. Vulvar squamous cell carcinoma (VSCC) accounts for more than 90% of malignant tumors of the vulva (3), with 2 different etiopathogenic pathways for its development. Vulvar disease is a rare affection of the lower genitalia, with incidence rates of 0.5-2.5 in 100,000 women (4% of gynecological malignancies) (1). Twenty-eight were excluded because patients received radiotherapy (1 study), the language was not English (7 studies), or the results were not compared with HPV testing (20 studies). Scopri quali alberi ha e tutto quello che sta facendo per rendere il mondo più verde. Nel dramma la Ginzburg disegna il ritratto di un matrimonio, di carattere piuttosto borghese, tra l'avvocato Pietro e Giuliana, una giovane donna di bassa estrazione sociale conosciuta ad una festa. Maria Grazia Cucinotta racconta il suo personaggio nel film NOmi e COgnomi, al cinema dal 14 maggio. By examining each work by its salient characteristics, we can highlight the following findings. p16INK4a positivity levels were considered significant when there was intense and diffuse nuclear and cytoplasmic staining. The impact of primary Sjogren's syndrome on female sexual function, Toki, T Kurman, RJ Park, JS Kessis, T Daniel, RW Shah, KV, van de Nieuwenhof, HP van Kempen, LC de Hullu, JA, van der Avoort, IA Shirango, H Hoevenaars, BM, Savone, D Carrone, A Riganelli, L Merlino, L Mancino, P Benedetti Panici, P, Hoevenaars, BM van der Avoort, IAM de Wilde, PCM, Riethdorf, S Neffen, EF Cviko, A Löning, T Crum, CP Riethdorf, L, Rufforny, I Wilkinson, EJ Liu, C Zhu, H Buteral, M Massoll, NA, Hay, CM Lachance, JA Lucas, FL Smith, KA Jones, MA, Reuschenbach, M Roos, J Panayotopoulos, D, Lawrie, TA Nordin, A Chakrabarti, M Bryant, A Kaushik, S Pepas, L, Herod, JJ Shafi, MI Rollason, TP Jordan, JA Luesley, DM, Benedetti Panici, P Di Donato, V Bracchi, C. View or download all content the institution has subscribed to. Technical problems, such as the varying sensitivity or the possibility of contamination, and the high cost of the molecular test employed for HPV investigation (HC2 or PCR assay) could be overcome by applying p16INK4a, p53 and/or Ki67 immunostaining. Join Facebook to connect with Mariagrazia Piccioni and others you may know. Il tuo nome. Maria Grazia Cucinotta. Also Reuschenbach et al (18) highlighted that hrHPV/p16 positivity is frequent in young women, irrespective of tumor site (anterior fourchette or other vulvar locations). La tua email. This video is unavailable. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions, If you have access to journal content via a university, library or employer, sign in here, Research off-campus without worrying about access issues. Table I Details and findings of included studies. Intervista alla Dott.ssa Maria Grazia Piccioni per il programma Live Social. PICCIONI Categoria: Animali; Pubblicato: Giovedì, 14 Novembre 2013 00:00 Scritto da Maria Grazia Sereni Stampa; Email; È in corso un’inchiesta sulle gare di volo dei piccioni in Belgio. View the profiles of people named Maria Grazia Pacchioni. Contatti; Categorie attivita. Lavasecco Azzurra di Fassari / Maria Grazia in Catania, reviews by real people. Search Google Scholar for this author, Felice Patacchiola, MD 4. LEARN MORE. One provided data on p16INK4a immunoreactivity in VIN (13); 2 in VIN plus VSCC (11, 14); another 2 in normal vulvar squamous epithelium, VIN and VSCC (15, 16); the remaining studies (8, 17, 18) evaluated only VSCC. Baidu: Search more result on Baidu about Spiller Dr. maria Grazia Ambulatorio Medico Pediatrico, Musile Di Piave, Italia Bing: Search more result on Bing about Spiller Dr. maria Grazia Ambulatorio Medico Pediatrico, Musile Di Piave, Italia Ecosia: Search more result on Ecosia about Spiller Dr. maria Grazia Ambulatorio Medico Pediatrico, Musile Di Piave, Italia In the study performed by Santos et al (11), 92 VSCC surgical specimens, consecutively and retrospectively identified, were examined for HPV DNA, p16INK4a and p53 positivity. The other is not hrHPV related but is more likely associated with chronic granulomatous diseases, squamous hyperplasia, or lichen sclerosus in the adjacent epithelium and may be associated with differentiated-type VIN (4, 5). the site you are agreeing to our use of cookies. HPV-related carcinogenesis is characterized by hrHPV DNA integration into the host DNA (10). views: 625 Maggio 22, 2019 2:23 pm. This overlapping may lead to a certain level of subjectivity, as reported by some authors (19, 20). In the retrospective study by Riethdorf et al (15), p16INK4a was assessed by a monoclonal antibody to correlate its positivity levels to those of HPV DNA (PCR amplified) in vulvar cancers compared with benign conditions. These findings could be useful to personalize surgical and adjuvant treatments basing on different molecular profiles, but in the patient series studied by Alonso et al (8) HPV/p16-positive VSCC showed a similar prognosis to HPV/p16-negative VSCC. La Dottoressa Piccioni è sempre attenta, professionale, scrupolosa. Maria Grazia Piccioni Department of Gynecological, Obstetrical and Urological Sciences, “Sapienza” University and Umberto I Polyclinic of Rome, Rome - Italy See all articles by this author. l meglio: Ho apprezzato molto il fatto che facesse molte domande, proprio per essere sicura di aver preso in considerazione tutte le ipotesi. Adi Shakti - Bhakti Mantra - Duration: 12:43. We included all English-language retrospective and prospective studies at primary diagnosis assessing p16INK4a immunostaining or p16INK4a/p53 staining, with HPV DNA testing (HC2/PCR) as the comparator test, on histological specimens of VIN and VSCC verified with a reference standard. This is in agreement with the findings of Rufforny et al (16), who demonstrated that HPV-related VIN is a “younger” pathology than HPV-negative vulvar tumors. Chiudendo questo banner, scorrendo questa pagina o cliccando qualunque suo elemento acconsenti all’uso dei cookie. Also, Ki67 immunostaining showed high, diffuse and nuclear positivity in uVIN, while it was absent or confined to the parabasal epithelial layer in dVIN and it was absent in normal epithelium. Patient age was unremarkable, with some exceptions: the mean age of women with HPV16 positivity (and the relative E6/E7 transcription) was significantly lower (p<0.001) than that of women with vulvar cancers not linked to HPV DNA. HPV DNA was identified in 16/92 samples (17.4%), while diffuse positivity for p16 and p53 was observed in 100% and 6.2% of HPV-positive tumors and in 2.3% and 64.5% of HPV-negative tumors, respectively. In the study by Hoevenaars et al (13), VIN specimens of 120 consecutive patients were examined: 75 had dVIN and 45 had uVIN. In warty or basaloid type VSCC, positivity for both HPV and p16INK4a was more frequent. HPV positivity and p16INK4a immunoreactivity detected in uVIN ranged from 80% to 100%, p53 immunostaining was positive in 0%-7% of cases, and MIB1 immunostaining was high in 98% of cases. Maria Grazia Piccioni is on Facebook. p53 nuclear immunostaining was always negative in HPV-related disease.

La Religione Nel Medioevo: Riassunto, Tabellina Del 9 Da Stampare, Vincitore Sanremo 2005, Frasi Sulla Negatività Tumblr, Asl Lungotevere Della Vittoria Centralino, Il Mondo è Mio Accordi, Angela Figliè Biografia,


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Conflict of interest: The authors declare they have no competing interests related to this article. Attualmente sono Dirigente Medico di I Livello con la qualifica universitaria di Ricercatore Confermato e sono Responsabile di Progetti di Ricerca. For more information view the SAGE Journals Sharing page. Management of HPV-Related Cervical Disease: Role of p16INK4a Immunochemistry. Oggetto. Join Facebook to connect with Maria Grazia Piccioni and others you may know. Dott.ssa Maria Grazia Carrara, Faculty of Statistics Department of Statistical Sciences, Università degli Studi di Milan-Bicocca. For Ki67 protein, immunoreactivity localization in the parabasal layers or in the lower third of the epithelium was considered “low-level”; Ki67 reactivity in the lower two-thirds or in the full-thickness epithelium was considered “high-level”. Address Sisters By MARIA GRAZIA DONDI - Via Jacopo da Porto Sud, 509, 41126 Baggiovara (MO) In the study by Santos et al (11), p16INK4a positivity was established when sheets or large clusters of contiguous positive cells representing more than 25% of epithelium were identifiable; also p53 nuclear immunostaining was considered positive when found in 25% or more of cells. Further, larger and controlled studies are needed to obtain consensus diagnostic results in order to use these markers in everyday clinical practice as a valid, effective and economically convenient instrument. In specimens of warty/basaloid VSCC, HPV positivity ranged from 62.5% to 100%, p16INK4a immunoreactivity from 76.4% to 100%, and p53 immunostaining was positive in 6.2% of cases. Does human papillomavirus infection imply a different prognosis in vulvar squamous cell carcinoma? Additionally, women with uVIN and no SCC areas had a still lower median age at the time of diagnosis: 36 years (SD 10.8 years). Maria Grazia Porpora 1 , Roberto Brunelli, Graziella Costa, Ludovica Imperiale, Ewa K Krasnowska, Thomas Lundeberg, Italo Nofroni, Maria Grazia Piccioni, Eugenia … The email address and/or password entered does not match our records, please check and try again. IARC. The initial findings of the patients and specimens surveyed were also specified. Reuschenbach et al (18) also evaluated VSCC based on HPV DNA, p16INK4a and p53 expression, with tumor location limited to the anterior vulvar fourchette. Buongiorno, sono la dottoressa Maria Grazia Piccioni e vi do il benvenuto sul mio profilo. Search Google Scholar for this author, Pierluigi Benedetti Panici. The sensitivity and specificity of p16INK4a to detect HPV-associated carcinomas were 100% and 98.7%, respectively, which compares favorably to histological criteria (with 93.8% sensitivity and 35.5% specificity) and to p53 negativity (with 62.5% sensitivity and 93.4% specificity). Normal vulvar epithelium, nondysplastic lesions and HPV-related uVIN and basaloid/warty VSCC were negative for p53, while nuclear and diffuse p53 immunostaining was detected in dVIN and keratinizing VSCC. Sono occupata anche in ambito accademico: sono infatti docente presso il Corso di laurea in Medicina e Chirurgia per la materia di Ostetricia e Ginecologia presso l'Università "La Sapienza" di Roma, nella quale io stessa mi sono lauerata. Cucinotta was born in Messina, Province of Messina, Sicily, Italy. Members of _ can log in with their society credentials below. Search Google Scholar for this author, Pierluigi Benedetti Panici. For more information please contact us. Aggiungi una recensione Fai … HPV16 was the predominant genotype, followed by HPV18 and HPV33. Maria Grazia Piccioni. Viviamo nel periodo molto strano, la gente no ha fiducia, non ci sentiamo sicuri. No age differences were found with respect to the other studies evaluated. Maria Di Grazia. Studies whose full manuscript or baseline characteristics were not available were excluded from our analysis. a case-control study: GYNECOLOGICAL ENDOCRINOLOGY: 2020: 5 recensioni, La Professoressa Maria e' meravigliosa. +2 Altro. +39 339 44 44 247 Casa Piccioni Strada Vecchia Passera-Vedasco 6 28838 Stresa Frazione Passera Italia MILANETTI ALESSANDRO . Login failed. Guarda il profilo completo su LinkedIn e scopri i collegamenti di Maria Grazia e le offerte di lavoro presso aziende simili. Cancer incidence in five continents, Probable nonpapillomavirus etiology of squamous cell carcinoma of the vulva in older women: a clinicopathologic study using in situ hybridization and polymerase chain reaction, Recent advances in the pathology of the vulva, Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee, The etiologic role of HPV in vulvar squamous cell carcinoma fine tuned. Il tuo messaggio. Per contattarmi puoi chiamare il numero +39 347 7868495 mandarmi una email. Most of them showed close areas positive for squamous cell carcinoma (SCC). Risulta sempre disponibile e, in caso di necessità, rintracciabile. The baseline characteristics of the studies were extracted from each article: the first author, journal and year of publication, and the number of specimens examined in relation to the number of patients. A systematic literature search was carried out in the online databases PubMed, EMBASE, Cochrane Library, Clincaltrials.gov and Scopus. Official FaceBook Fan Page Review studies indicated that p16INK4a or p16INK4a/p53 immunoreactivity along with histological diagnostics could adequately classify VIN and its connection to HPV infection. Contatti. Maria Grazia Piccioni; Maria Grazia. A risk of bias across the assessed studies was due to the not perfectly homogeneous interpretation of p16INK4a expression and the different kits used for immunostaining; thus, it will be necessary to standardize the nuclear and cytoplasmic scoring system and the immunohistochemistry technique. Facebook gives people the power to share … Maria Grazia Porpora 1 , Roberto Brunelli, Graziella Costa, Ludovica Imperiale, Ewa K Krasnowska, Thomas Lundeberg, Italo Nofroni, Maria Grazia Piccioni, … Join Facebook to connect with Maria Grazia Piccini and others you may know. p16INK4a, HPV DNA, MIB1 and p53 were examined using immunohistochemical staining, which identified nuclear positivity. Maria Grazia Piccioni . Infatti, si è scoperto che molti dei volatili vengono drogati con cocaina o antidolorifici. However, its expression in vulvar carcinomas, which have a diverse pathogenesis, has not been extensively studied and only a few studies were reported in the scientific literature. oppure compilare il modulo qui di seguito. The key search terms were HPV, VIN, p16INK4a immunochemistry and p53. The remaining 8 studies were included in the review. I have read and accept the terms and conditions, View permissions information for this article. Lavasecco Azzurra di Fassari / Maria Grazia - Laundry Services - Via dei Piccioni, 11, Catania, Italy - Phone Number - … Maria Grazia Piccioni is on Facebook. Adnexal masses are not common in pregnancy. Journal of prenatal medicine, 1 (2). Ho sempre ritenuto la ginecologia una materia importante e necessaria per il benessere della donna e per questa ragione, dopo la laurea in Medicina e Chirurgia, mi sono specializzata presso l'Università La Sapienza di Roma in Ginecologia ed Ostetricia. Facebook gives people the power to share … Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Therefore, the clear recognition of HPV-related lesions should lead to an appropriate strategy of treatment and follow-up. For HPV-related basaloid/warty VSCC, p16INK4 immunostaining was able to distinguish transforming HPV infections better than HPV DNA detection and with higher interobserver agreement. We found that nuclear and cytoplasmic immunostaining for p16INK4a was intense and diffuse in HPV-associated lesions and weak and focal in normal vulvar epithelium, nondysplastic lesions, lichen sclerosus and keratinizing vulvar squamous cell carcinoma. Vulvar squamous cell carcinoma (VSCC) accounts for more than 90% of malignant tumors of the vulva (3), with 2 different etiopathogenic pathways for its development. Vulvar disease is a rare affection of the lower genitalia, with incidence rates of 0.5-2.5 in 100,000 women (4% of gynecological malignancies) (1). Twenty-eight were excluded because patients received radiotherapy (1 study), the language was not English (7 studies), or the results were not compared with HPV testing (20 studies). Scopri quali alberi ha e tutto quello che sta facendo per rendere il mondo più verde. Nel dramma la Ginzburg disegna il ritratto di un matrimonio, di carattere piuttosto borghese, tra l'avvocato Pietro e Giuliana, una giovane donna di bassa estrazione sociale conosciuta ad una festa. Maria Grazia Cucinotta racconta il suo personaggio nel film NOmi e COgnomi, al cinema dal 14 maggio. By examining each work by its salient characteristics, we can highlight the following findings. p16INK4a positivity levels were considered significant when there was intense and diffuse nuclear and cytoplasmic staining. The impact of primary Sjogren's syndrome on female sexual function, Toki, T Kurman, RJ Park, JS Kessis, T Daniel, RW Shah, KV, van de Nieuwenhof, HP van Kempen, LC de Hullu, JA, van der Avoort, IA Shirango, H Hoevenaars, BM, Savone, D Carrone, A Riganelli, L Merlino, L Mancino, P Benedetti Panici, P, Hoevenaars, BM van der Avoort, IAM de Wilde, PCM, Riethdorf, S Neffen, EF Cviko, A Löning, T Crum, CP Riethdorf, L, Rufforny, I Wilkinson, EJ Liu, C Zhu, H Buteral, M Massoll, NA, Hay, CM Lachance, JA Lucas, FL Smith, KA Jones, MA, Reuschenbach, M Roos, J Panayotopoulos, D, Lawrie, TA Nordin, A Chakrabarti, M Bryant, A Kaushik, S Pepas, L, Herod, JJ Shafi, MI Rollason, TP Jordan, JA Luesley, DM, Benedetti Panici, P Di Donato, V Bracchi, C. View or download all content the institution has subscribed to. Technical problems, such as the varying sensitivity or the possibility of contamination, and the high cost of the molecular test employed for HPV investigation (HC2 or PCR assay) could be overcome by applying p16INK4a, p53 and/or Ki67 immunostaining. Join Facebook to connect with Mariagrazia Piccioni and others you may know. Il tuo nome. Maria Grazia Cucinotta. Also Reuschenbach et al (18) highlighted that hrHPV/p16 positivity is frequent in young women, irrespective of tumor site (anterior fourchette or other vulvar locations). La tua email. This video is unavailable. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions, If you have access to journal content via a university, library or employer, sign in here, Research off-campus without worrying about access issues. Table I Details and findings of included studies. Intervista alla Dott.ssa Maria Grazia Piccioni per il programma Live Social. PICCIONI Categoria: Animali; Pubblicato: Giovedì, 14 Novembre 2013 00:00 Scritto da Maria Grazia Sereni Stampa; Email; È in corso un’inchiesta sulle gare di volo dei piccioni in Belgio. View the profiles of people named Maria Grazia Pacchioni. Contatti; Categorie attivita. Lavasecco Azzurra di Fassari / Maria Grazia in Catania, reviews by real people. Search Google Scholar for this author, Felice Patacchiola, MD 4. LEARN MORE. One provided data on p16INK4a immunoreactivity in VIN (13); 2 in VIN plus VSCC (11, 14); another 2 in normal vulvar squamous epithelium, VIN and VSCC (15, 16); the remaining studies (8, 17, 18) evaluated only VSCC. Baidu: Search more result on Baidu about Spiller Dr. maria Grazia Ambulatorio Medico Pediatrico, Musile Di Piave, Italia Bing: Search more result on Bing about Spiller Dr. maria Grazia Ambulatorio Medico Pediatrico, Musile Di Piave, Italia Ecosia: Search more result on Ecosia about Spiller Dr. maria Grazia Ambulatorio Medico Pediatrico, Musile Di Piave, Italia In the study performed by Santos et al (11), 92 VSCC surgical specimens, consecutively and retrospectively identified, were examined for HPV DNA, p16INK4a and p53 positivity. The other is not hrHPV related but is more likely associated with chronic granulomatous diseases, squamous hyperplasia, or lichen sclerosus in the adjacent epithelium and may be associated with differentiated-type VIN (4, 5). the site you are agreeing to our use of cookies. HPV-related carcinogenesis is characterized by hrHPV DNA integration into the host DNA (10). views: 625 Maggio 22, 2019 2:23 pm. This overlapping may lead to a certain level of subjectivity, as reported by some authors (19, 20). In the retrospective study by Riethdorf et al (15), p16INK4a was assessed by a monoclonal antibody to correlate its positivity levels to those of HPV DNA (PCR amplified) in vulvar cancers compared with benign conditions. These findings could be useful to personalize surgical and adjuvant treatments basing on different molecular profiles, but in the patient series studied by Alonso et al (8) HPV/p16-positive VSCC showed a similar prognosis to HPV/p16-negative VSCC. La Dottoressa Piccioni è sempre attenta, professionale, scrupolosa. Maria Grazia Piccioni Department of Gynecological, Obstetrical and Urological Sciences, “Sapienza” University and Umberto I Polyclinic of Rome, Rome - Italy See all articles by this author. l meglio: Ho apprezzato molto il fatto che facesse molte domande, proprio per essere sicura di aver preso in considerazione tutte le ipotesi. Adi Shakti - Bhakti Mantra - Duration: 12:43. We included all English-language retrospective and prospective studies at primary diagnosis assessing p16INK4a immunostaining or p16INK4a/p53 staining, with HPV DNA testing (HC2/PCR) as the comparator test, on histological specimens of VIN and VSCC verified with a reference standard. This is in agreement with the findings of Rufforny et al (16), who demonstrated that HPV-related VIN is a “younger” pathology than HPV-negative vulvar tumors. Chiudendo questo banner, scorrendo questa pagina o cliccando qualunque suo elemento acconsenti all’uso dei cookie. Also, Ki67 immunostaining showed high, diffuse and nuclear positivity in uVIN, while it was absent or confined to the parabasal epithelial layer in dVIN and it was absent in normal epithelium. Patient age was unremarkable, with some exceptions: the mean age of women with HPV16 positivity (and the relative E6/E7 transcription) was significantly lower (p<0.001) than that of women with vulvar cancers not linked to HPV DNA. HPV DNA was identified in 16/92 samples (17.4%), while diffuse positivity for p16 and p53 was observed in 100% and 6.2% of HPV-positive tumors and in 2.3% and 64.5% of HPV-negative tumors, respectively. In the study by Hoevenaars et al (13), VIN specimens of 120 consecutive patients were examined: 75 had dVIN and 45 had uVIN. In warty or basaloid type VSCC, positivity for both HPV and p16INK4a was more frequent. HPV positivity and p16INK4a immunoreactivity detected in uVIN ranged from 80% to 100%, p53 immunostaining was positive in 0%-7% of cases, and MIB1 immunostaining was high in 98% of cases. Maria Grazia Piccioni is on Facebook. p53 nuclear immunostaining was always negative in HPV-related disease.

La Religione Nel Medioevo: Riassunto, Tabellina Del 9 Da Stampare, Vincitore Sanremo 2005, Frasi Sulla Negatività Tumblr, Asl Lungotevere Della Vittoria Centralino, Il Mondo è Mio Accordi, Angela Figliè Biografia,


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